Nucleosides and Analogues
Medchemexpress LLC Alpha-Guanosine | 15398-66-0 | C10H13N5O5 | 25 MG
Alpha-Guanosine is a purine nucleoside analog that exhibits broad antitumor activity against indolent lymphoid malignancies. Its anticancer mechanisms involve inhibiting DNA synthesis and inducing apoptosis.
- Purine nucleoside analog
- Exhibits broad antitumor activity
- Targets indolent lymphoid malignancies
- Inhibits DNA synthesis
- Induces apoptosis
Medchemexpress LLC Adenosine 5'-triphosphate(ATP)-d4 ammonium salt | 2483831-82-7 | C10H24D4N9O13P3 | 1.16 MG
Adenosine 5'-triphosphate(ATP)-d4 (ammonium salt) is the deuterium labeled Adenosine 5'-triphosphate(ATP) ammonium salt. It is intended for research use only.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Apexbio Technology LLC ATP(Synonyms: Adenosine triphosphate, Adenosine 5'-triphosphate, Adenosine-5'-triphosphoric acid), 500mg, CAS: 56-65-5.
Adenosine triphosphate (ATP CAS 56-65-5) is a nucleoside triphosphate comprising adenine linked to ribose with three phosphate groups esterified sequentially ATP primarily functions as a universal energy carrier in cellular metabolism transferring phosphate groups to facilitate enzymatic reactions and drive biological activities Additionally ATP acts extracellularly as a neurotransmitter and signaling molecule binding purinergic receptors to modulate physiological responses such as neurotransmission vascular tone inflammation and immune cell function Due to its versatile biological roles ATP is extensively employed in biomedical research investigating metabolic pathways receptor signaling dynamics and cellular energetics
Medchemexpress LLC GTP-14564 | 34823-86-4 | MFCD01416326 | 99.9% | 234.25 g·mol⁻¹ | C15H10N2O | 5 MG
GTP-14564 is a small-molecule tyrosine kinase inhibitor selective for internal tandem duplication (ITD) mutant and wild-type FLT3. It inhibits FLT3 ligand-dependent proliferation of Ba/F3 leukemia cells and is used as a research tool to study FLT3-driven signaling and leukemogenesis. Chemical formula C15H10N2O; molecular weight 234.25 g·mol⁻¹; reported purity 99.91%.
- Targets ITD and wild-type FLT3.
- Inhibits FLT3 ligand-dependent growth in Ba/F3 cells.
- High reported purity suitable for biochemical assays.
- Compact quantity suitable for screening and small-scale studies.
- Documented in chemical databases and literature for FLT3 research.
Apexbio Technology LLC 2'-O-Methyl-N6-Methyl-ATP 50ul (100 mM)
2p-O-Methyl-N6-Methyl-ATP is a chemically modified ATP analog bearing methyl substitutions at the N6 position of adenine and the 2 -hydroxyl group of the ribose sugar 2p-O-Methyl-N6-Methyl-ATP is designed to facilitate the study of RNA methylation processes and RNA protein interactions supporting the mechanistic exploration of RNA-modifying enzymes and epigenetic regulatory pathways Based on these properties 2p-O-Methyl-N6-Methyl-ATP holds research potential in investigations of ligand RNA interactions and drug discovery applications targeting RNA-related biological processes
Medchemexpress LLC AZT triphosphate tet 10mg | 106060-92-8 | 10 MG
AZT triphosphate tetraammonium is the tetraammonium salt of the active triphosphate metabolite of zidovudine (AZT). It is used as a biochemical reagent in virology and nucleotide metabolism studies where the active nucleotide analog is required. The product is supplied with a certificate of analysis and safety data sheet and is intended for research use only.
- Active triphosphate metabolite of zidovudine (AZT) for biochemical assays.
- High chemical purity suitable for analytical and cellular studies.
- Available as a solid in multiple milligram sizes and as a 10 mM solution in DMSO.
- Supplied with certificate of analysis and safety data sheet for quality and handling information.
- Recommended storage: sealed at -20°C; in solvent store at -80°C for up to 6 months.
Medchemexpress LLC Guanosine 5'-triphosphate trisodium salt hydrate | 207300-85-4 | 95.0% | 50 MG
Guanosine 5'-triphosphate trisodium salt hydrate (5'-GTP trisodium salt hydrate) is a chemical reagent that functions as an activator for signal transducing G proteins. It also serves as an energy-rich precursor of mononucleotide units, which are essential for the enzymatic biosynthesis of DNA and RNA. This product is intended for research use only.
- Functions as an activator for signal transducing G proteins.
- Serves as an energy-rich precursor of mononucleotide units.
- Essential for the enzymatic biosynthesis of DNA and RNA.
- Intended for research use only.
Medchemexpress LLC Alpha guanosine | 15398-66-0 | 96.0% | 283.24 g/mol | C10H13N5O5 | 10 MG
Alpha guanosine is a purine nucleoside analog used in biochemical and pharmacological research to study nucleoside metabolism and antimetabolite activity. The product is supplied as a purified powder with documented physicochemical properties, recommended storage conditions, and solubility information to support preparation of stable stock solutions for laboratory use.
- Purity: 95.96%
- Molecular formula: C10H13N5O5
- Molecular weight: 283.24 g/mol
- Soluble in DMSO at 12.5 mg/mL with ultrasonic warming to 60°C
- Powder recommended storage: -20°C, stable for up to 3 years
- In-solution stability: -80°C for 6 months, -20°C for 1 month
- Available in small milligram pack sizes for research applications
Medchemexpress LLC Adenosine 5'-O-(2-thiodiphosphate) trilithium salt | 73536-95-5 | MFCD00077314 | 94.9% | C10H12Li3N5O9P2S | 10MG
ADP-β-S trilithium is the trilithium salt of adenosine 5'-β-thiodiphosphate, used in research as a P2Y12 receptor activator. It is supplied as a white to off-white solid (CAS 73536-95-5) with listed purity ~94.9% and molecular formula C10H12Li3N5O9P2S. Store sealed and away from moisture; in solution store at -80°C for long-term stability.
- Activator of P2Y12 receptor in cellular assays.
- Upregulates IL-1β and IL-6 production in microglial models.
- Promotes NF-κB phosphorylation and nuclear translocation.
- Enhances NLRP3 inflammasome activation in relevant studies.
- Provided as a solid suitable for preparation of assay solutions.
- Stable under recommended sealed, low-temperature storage conditions.
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 100mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
eMolecules 990-91-0 | Tetrabenzyl Pyrophosphate | AA Blocks LLC | MFCD00051941 | 538.473 | C28H28O7P2 | 0.000 | O=P(OCc1ccccc1)(OCc1ccccc1)OP(=O)(OCc1ccccc1)OCc1ccccc1 | 5g | 436007791
Tetrabenzyl Pyrophosphate | AA Blocks LLC | 990-91-0 | MFCD00051941 | 538.473 | C28H28O7P2 | 0.000 | O=P(OCc1ccccc1)(OCc1ccccc1)OP(=O)(OCc1ccccc1)OCc1ccccc1 | 5g | 436007791
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 10mM (in 1mL DMSO)
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
TARGETMOL CHEMICALS INC ADENOSINE ANTAGONIST-1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Adenosine antagonist-1 acts as an adenosine A3 receptor (AA3R) antagonist. purity: 99%
Medchemexpress LLC Potassium diphosphate | 7320-34-5 | MFCD00011393 | 1kg
Potassium diphosphate (tetra-Potassium pyrophosphate) is a kind of biological materials or organic compounds that are widely used in life science research[1]
Apexbio Technology LLC 2-Amino-ATP(Synonyms: 2-NH2-ATP, 2-Aminoadenosine triphosphate, 2-Amino-adenosine-5'-triphosphate, 2-Amino-ATP (free acid)), 100ul (100 mM).
2-Amino-ATP is a modified nucleotide structurally related to ATP (adenosine triphosphate) featuring an amino substitution at the adenine ring s 2-position It acts as an ATP analog capable of competitively binding at the active sites of ATP-dependent enzymes potentially modulating their enzymatic activity and influencing downstream signaling pathways In research settings 2-Amino-ATP serves as a molecular tool to examine substrate specificity mechanistic aspects of ATP-binding enzymes (e g kinases and ATPases) and nucleotide-dependent receptor interactions facilitating studies of nucleotide signaling and cellular metabolism