Nucleosides and Analogues
Medchemexpress LLC 2'-Deoxyuridine-1'-13C | 478510-85-9 | 5 MG
2'-Deoxyuridine-1'-13C is a carbon-13 labeled version of 2'-Deoxyuridine. This compound induces chromosome breakage, thereby reducing the synthesis activity of thymidylate. Additionally, it serves as a precursor in the synthesis of Edoxudine.
- Carbon-13 labeled version of 2'-Deoxyuridine.
- Induces chromosome breakage.
- Reduces synthesis activity of thymidylate.
- Serves as a precursor in the synthesis of Edoxudine.
Medchemexpress LLC Lamivudine (BCH-189) | 134678-17-4 | 99.9% | 1 ML
Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI) that inhibits HIV reverse transcriptase 1/2 and the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS.
- Used in studies involving VSMCs for staining and calcium content analysis.
- Applied in Western blot analysis for various protein markers in VSMCs.
- Utilized in animal models to study serum creatinine levels and aortic calcification.
- Suitable for immunohistochemical staining and analysis of osteogenic and contractile phenotypic markers.
Medchemexpress LLC Nicotinamide (standard) | 98-92-0 | 99.85% | 250 MG
Nicotinamide (Standard) is the analytical standard of Nicotinamide, a form of vitamin B3 or niacin, intended for research and analytical applications. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
- Inhibits SIRT2 activity (IC50: 2 μM)
- Inhibits SIRT1
- Increases cellular NAD+, ATP, ROS levels
- Inhibits tumor growth and improves survival
- Has anti-HBV activity
Sigma Aldrich Fine Chemicals Biosciences Guanosine 5 betagama imi100MG
Guanosine 5prime-[beta gamma-imido]triphosphate (GMP-PNP Gpp(NH)p) is a non-hydrolyzable analog of GTP that binds and irreversibly activates G proteins. Gpp(NH)p is used in a variety of applications that involve GTP binding including GTP-activation GTP-inhibition GTP transport GTP hydrolysis and GTP structure stabilization. Since a cycle of GTP binding hydrolysis and release is required for the initiation of protein translocation across the endoplasmic reticulum guanosine 5prime-[beta gamma-imido]triphosphate is often used in studies of protein synthesis. Gpp(NH)p is used to activate ADP-ribosylation factors and to modulate G proteins involved in cell signaling protein synthesis and other metabolic processes.
Medchemexpress LLC Adenosine 5'-triphosphate-13C10 (dilithium) | 99.3% | 1 MG
ATP-13C10 dilithium is a 13C-labeled adenosine 5'-triphosphate. It is a central component of energy storage and metabolism in vivo, providing metabolic energy and serving as a coenzyme in cells. This compound is also an important endogenous signaling molecule in immunity and inflammation.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Adenosine 3',5'-diphosphate disodium | 75431-54-8 | 99.1% | 471.16 | 1 MG
Adenosine 3',5'-diphosphate disodium is an hydroxysteroid sulfotransferases inhibitor. It is for research use only and not sold to patients.
- Hydroxysteroid sulfotransferases inhibitor
- For research use only
- Not sold to patients
- Soluble in H2O at ≥ 25 mg/mL (53.06 mM)
- Store at -20°C, sealed, away from moisture
- In solvent, store at -80°C (6 months) or -20°C (1 month), sealed, away from moisture
Medchemexpress LLC GTP-14564 | 34823-86-4 | 99.9% | 234.25 | 10 MG
GTP-14564 is a tyrosine kinase inhibitor that targets internal tandem duplication (ITD) and FLT3. It inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells.
- Tyrosine kinase inhibitor
- Targets ITD and FLT3
- Inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells
- Available in various quantities
- Available as solid or in solution (10 mM in DMSO)
- Off-white to yellow solid appearance
- For research use only
- Has a data sheet, COA, SDS, and handling instructions available
Sigma Aldrich Fine Chemicals Biosciences D-GLUCOSAMINE 6-PHOSPHATE
NC3840093 D-GLUCOSAMINE 6-PHOSPHATE
Medchemexpress LLC Tenofovir diphosphate disodium | 2738719-07-6 | 99.42% | 491.14 | 1 MG
Tenofovir diphosphate disodium is an antiretroviral agent primarily used for AIDS research. It acts as an inhibitor of HIV reverse transcriptase DNA (Ki = 1.55 μM) and RNA (Ki = 0.022 μM). This compound exhibits minimal inhibitory effect on eukaryotic DNA replication in vitro.
- Antiretroviral agent
- Inhibits HIV reverse transcriptase DNA and RNA
- Used for AIDS research
- Minimal inhibitory effect on eukaryotic DNA replication in vitro
Sigma Aldrich Fine Chemicals Biosciences beta Nicotinamide adenine
-Nicotinamide adenine dinucleotide (-NAD) is a ubiquitous biomolecule containing an adenylic acid and a nicotinamide-5AE-ribonucleotide group linked together by a pyrophosphate moiety. In NAD complexes the enzyme-cofactor interactions are highly conserved.
Sigma Aldrich Fine Chemicals Biosciences 5-fluoro-2-deoxyuridine 5-5MG
5-fluoro-2-deoxyuridine 5-5MG
Sigma Aldrich Fine Chemicals Biosciences Adenosine 13C1015N5 5 trip10MG
Adenosine 13C1015N5 5 trip10MG
Apexbio Technology LLC 2'-O-Methyl-ATP(Synonyms: 2'-O-Methyladenosine 5'-triphosphate, 2'-OMe-ATP, ATP 2'-O-Methyl analog), 100ul (100 mM).
2 -O-Methyl-ATP is a chemically modified derivative of ATP in which the hydroxyl group at the ribose 2 position is replaced with a methyl group This ribose modification confers resistance to nuclease-mediated degradation thereby increasing its biological stability The modified nucleotide is commonly employed in biomedical research to investigate RNA structure-function relationships and RNA modification pathways and to study interactions influencing RNA polymerase specificity and catalytic activity Additionally 2 -O-Methyl-ATP serves as a tool in probe design for RNA interference experiments and aids in elucidating intracellular metabolic pathways involving nucleotide analogs